Relationship between cluster miR-143/145 micro-RNAs with oncogenesis: tissue and cellular context

The purpose of the study was to present up-to-date data on regulation expression, function in normal tissues and multidirectional activity oncogenesis miR-143/145 microRNAs cluster, as well evaluate possibilities limitations therapeutic use this cluster malignant neoplasms. Material methods . search for available domestic foreign literary sources published PubMed RSCI databases over past 10 years has been carried out. 427 articles were found, which 41 included review. Results conservative is one most intensively studied tumors. Based results analysis differential miRNA vitro experiments cancer cell lines vivo mouse tumor models, a decrease miR-143 miR-145 levels shown neoplasms epithelial origin. Until recently, these miRNAs considered classical oncosuppressors. presented review demonstrate that number studies taking into account cellular aspects microRNA expression contradict concept. microRNA, example, known participate metabolic restructuring activation neoangiogenesis. It oncosuppressive or pro-oncogenic depend tissue context can be explained by presence several regulated targets have opposite effects oncogenesis. Taken together, obtained suggest need exercise caution when choosing described exogenous delivery. Conclusion Further detailed decoding mechanisms functioning various types cells, identification new MRNA are necessary better understanding involvement molecules